Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Arthropoda (incl. insects and spiders)
Insecta (insects)
Diptera (true flies)
Culicidae (mosquitoes)
Anopheles (marsh mosquitoes)
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR variant - 'Integral gene drive' targeting nanos
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR targeting the Agcd (cardinal) gene with compound cargo constructs. Two different strains generated named AgTp24 and AgTp43.
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector
Type of system
Homing gene drive using I-Sce1
African malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector
Type of system
Homing CRISPR
common malaria mosquito
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of pathogens (including malaria and lymphatic filariasis) by these vectors in North America
Type of system
Homing CRISPR (probably)
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in India and surrounding regions)
Type of system
Homing CRISPR
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector
Type of system
Homing CRISPR
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Southern Asia, the Arabian Peninsula and East Africa)
Type of system
Split homing CRISPR targeting doublesex gene
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Southern Asia, the Arabian Peninsula and East Africa)
Type of system
Homing gene drive targeting doublesex gene
Asian malaria mosquito
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
The aim is to 'pave the way for future gene drive designs with multiple sgRNAs expressed by multiple RNA Pol III promoters to mitigate resistance.'
Type of system
Split homing CRISPR targeting cardinal gene - four variants with different promoters for the sgRNA