Gene Drive Projects
Select one or more options to filter by taxonomic groups.
Animalia
Chordata (incl. vertebrates e.g. mammals and birds)
Mammalia (mammals)
Lagomorpha (Rabbits and hares)
European rabbit
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Eradication of invasive rabbit populations on islands to address biodiversity impacts; Impacts of rabbits on agriculture are also noted
Type of system
Homing CRISPR – two variants modelled
European rabbit
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Eradication at continental scale, presumably in Australia, to address impacts on biodiversity.
Type of system
Homing CRISPR or ‘Y-linked X shredder’- Y-chromosome-linked X-shredder
European rabbit
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
Control or eradication of this invasive species in Australia - to address biodiversity and agricultural impacts.
Type of system
Homing CRISPR
European rabbit
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
Eradication of this species where it is invasive, e.g. New Zealand
Type of system
Homing CRISPR
European rabbit
Publications
Intended use
Control or eradication of this invasive species in Australia - to address biodiversity impacts
Animalia
Chordata (incl. vertebrates e.g. mammals and birds)
Mammalia (mammals)
Rodentia (rodents)
Cricetidae (incl. voles, hamsters, new world rats and mice)
Peromyscus (deer mice)
White footed mouse
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
To modify wild populations of this species to render them resistant to the bacteria causing Lyme’s disease, and thus reduce spread of this disease to humans
Type of system
Not stated
White footed mouse
Readiness of Technology
1 - Gene drive proposedPublications
Intended use
To modify wild populations of this species to render them resistant to the bacteria causing Lyme’s disease, and thus reduce spread of this disease to humans
Type of system
CRISPR daisy drive
Muridae (mice, rats, and gerbils)
Mus (mice)
House mouse
Readiness of Technology
4b - research on gene drive construction has taken place but evidence so far shows this approach doesn't workPublications
Intended use
Suppressing/eradicating invasive rodents on islands, and reducing impacts of rodents on agriculture
Type of system
Split homing gene drive
House mouse
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Initial aims: 1) using gene drive technology to create lab mouse strains carrying multiple modifications (with otherwise impractical genotypes) for laboratory studies 2) finding a way to eliminate invasive rodent species or addressing rodent-borne disease
Type of system
Homing CRISPR
House mouse
Readiness of Technology
4a - Active research on gene drive constructionIntended use
The aim is to improve pest control methods according to 2017 press release.
Type of system
Homing CRISPR (targeting ‘haplosufficient female fertility gene’)