Gene Drive Projects
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Fungi
Ascomycota (sac fungi)
Saccharomycetes (budding yeasts)
Saccharomycetales (budding yeasts)
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To create single and double deletion mutants in this species for laboratory studies.
Type of system
Split homing CRISPR
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Proof of principle of population modification via a split homing gene drive in this model organism.
Type of system
Split homing CRISPR
brewer’s or baker’s yeast
Readiness of Technology
4a - Active research on gene drive constructionPublications
Intended use
To study gene drives over many generations to understand the emergence of resistance.
Type of system
Probably homing CRISPR (as team had used this technology in other work)
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To test various methods to modulate gene drive activity, e.g. Cas9 expression level (Roggenkamp et al. 2018) and Cas9 nuclear localisation (Goeckel et al. 2019).
Type of system
Split homing CRISPR
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To test a split gene drive system to simultaneously propagate gene drives at three different loci
Type of system
Multi-locus split homing CRISPR
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Proof of principle of population modification via a split homing gene drive based on Cas12a.
Type of system
Split homing CRISPR employing Cas12a
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To generate a library of ‘all combinations of 10 missense mutations from across the genome’ to study interactions between these mutations (epistasis).
Type of system
Split homing CRISPR
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To generate homozygous diploid states in modified yeast
brewer’s or baker’s yeast
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
To readily combine genetically engineered loci in yeast
Sordariomycetes
Hypocreales
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
To modify populations of F. graminearum to disrupt virulence factors in this species, and so reduce head blight in wheat and barley
Type of system
Engineered gene drive employing Spok1 (spore killer meiotic drive from Podospora spp.)