Homing CRISPR for population modification in Anopheles gambiae with compound effector genes - UC Irvine

African malaria mosquito

Intended use

Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)

Readiness of Technology

5 - Limited proof of concept in laboratory

Project leader

James AA

Institution

University of California Irvine, USA

Publications

Authors name for system

'Population modification gene drive' with 'compound effector genes'

Class of Technology

Split homing gene drive

Field(s) of application

Vector control

Description of system

Homing CRISPR targeting the Agcd (cardinal) gene with compound cargo constructs. Two different strains generated named AgTp24 and AgTp43.

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population modification/replacement