'X-shredder' in Ceratitis capitata - Imperial College

Mediterranean fruit fly (or medfly)

Intended use

Reduction of damage to fruit crops caused by this species

Readiness of Technology

5 - Limited proof of concept in laboratory

Project leader

Windbichler N

Institution

Imperial College London UK

Publications

Authors name for system

CRISPR based sex distortion

Class of Technology

Sex ratio distorter

Field(s) of application

Agriculture

Description of system

Autosomal sex ratio distorter 'X-shredder'

Description

CRISPR based autosomal ‘X-shredder’ sex ratio distorter

Notes on readiness of technology

Limited proof of concept - the level of sex ratio distortion is quite low

Phenotype

68% male progeny from ‘highest performing strain’

Authors name for construct(s) - old

Most effective strains are designated Cas9.2a to d

Research in target organism

✔

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication