Preliminary work towards homing CRISPR rescue gene drives in Rattus Norvegicus - University of Adelaide

Brown rat

Intended use

'landscape-scale suppression of rodent populations' with use in 'eradication efforts on large islands' noted as a possibility

Project leader

Thomas PQ

Institution

University of Adelaide, Australia

Publications

Birand et al, 2025

Authors name for system

'homing rescue (HR) drive embedded in a haplolethal gene that also targets an independent fertility or viability gene'

Class of Technology

Homing gene drive

Field(s) of application

Conservation

Additional notes

The paper also mentions Rattus species in general as a target.

Description of system

Homing CRISPR 'rescue' embedded in haplolethal gene that also targets independent gene - three variants modelled targeting: (i) a female fertility gene, (ii) a male fertility gene, and (iii) a viability gene

For specialists

Research in target organism

✖

Research in model organism

✖

Intended for release

✔

Intended direct effects

Population suppression/eradication