'X-shredder’ (CRISPR based) in Anopheles gambiae - Imperial College

African malaria mosquito

Intended use

Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)

Readiness of Technology

6 - Laboratory proof of concept

Project leader

Crisanti A

Institution

Imperial College London UK

Publications

Authors name for system

CRISPR-Cas9 sex ratio distortion system

Class of Technology

Sex ratio distorter

Field(s) of application

Vector control

Description of system

Autosomal sex ratio distorter 'X-shredder' (CRISPR based)

Description

CRISPR based autosomal ‘X-shredder’ sex ratio distorter

Notes on readiness of technology

Appears to be validated in laboratory trials (but less effective than I-PpoI nuclease based system described in other A. gambiae projects)

Phenotype

86 to 95% male bias

Authors name for construct(s)

CRISPR-Cas9 sex ratio distortion system

Authors name for construct(s) - old

CRISPR^SD

Research in target organism

✔

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication