'Y-shredder' (CRISPR based) in Anopheles gambiae - Imperial College

Intended use

Potential to inform development of similar systems ' in other pest species where the female sex is not directly causing harm...'

Readiness of Technology

6 - Laboratory proof of concept

Project leader

Bernardini F

Institution

Imperial College London UK

Publications

Vitale et al., 2024

Authors name for system

'Y-shredder'

Class of Technology

Sex ratio distorter

Field(s) of application

General research and development

Additional notes

The authors state ' a vector control strategy based on biassing the progeny towards females would not be desirable for our target species, given that malaria is transmitted by the bite of infected female mosquitoes'

Description of system

An autosomal sex ratio distorter employing CRISPR-cas9 to target 'Y-chromosome specific sequences'

For specialists

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication