Split 'hierarchical' homing CRISPR gene drive in Saccharomyces cerevisiae - Harvard University

brewer’s or baker’s yeast

Intended use

To generate a library of ‘all combinations of 10 missense mutations from across the genome’ to study interactions between these mutations (epistasis).

Readiness of Technology

6 - Laboratory proof of concept

Project leader

Desai MM

Institution

Harvard University, USA

Publications

Bakerlee et al., 2022

Authors name for system

‘hierarchical’ CRISPR gene drive

Class of Technology

Homing gene drive

Field(s) of application

General research and development

Additional notes

It is uncertain if research has indeed progressed to the stage of laboratory proof of concept

Description of system

Split homing CRISPR

For specialists

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population modification/replacement