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Tracking plans to genetically modify wild species
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T-haplotype & CRISPR based split drive targeting female fertility in Mus musculus - University of Adelaide
Mus musculus
House mouse
Intended use
To explore the potential of an engineered form of the T-haplotype for ‘mouse population suppression or even eradication on islands’
Readiness of Technology
5 - Limited proof of concept in laboratory
Project leader
Thomas PQ
Institution
University of Adelaide, Australia
Project leader
Piaggio AJ
Institution
USDA National Wildlife Research Center, USA
Publications
Gierus et al., 2022
Piaggio et al., 2024
Birand et al, 2025
Authors name for system
tCRISPR split drive
Class of Technology
Other gene drive system
Field(s) of application
Conservation
Description of system
Split drive: a) T-haplotype element with gRNA cargo targeting ‘haplosufficient female fertility gene’ (Prl); b) Cas9 expressed separately (in male germline)
For specialists
Research in target organism
✖
Research in model organism
✖
Intended for release
✔
Intended direct effects
Population suppression/eradication