Preliminary work towards a homing CRISPR gene drive in Mus musculus - modelled design II - University of Adelaide

House mouse

Intended use

‘eradication of alien rodents on islands’ to address impacts on biodiversity; Aim ultimately is also to address impacts of alien rodents (esp. mice and rabbits) on agricultural production

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Thomas PQ

Institution

University of Adelaide, Australia

Publications

Prowse et al., 2017

Authors name for system

‘CRISPR gene drive’; Variants named: ‘Heterozygotic XX sterility’ ; ‘Heterozygotic XX sex reversal’

Class of Technology

Homing gene drive

Field(s) of application

Agriculture

Conservation

Description of system

Homing CRISPR - four designs modelled

For specialists

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication