Preliminary work towards a homing CRISPR gene drive in Tribolium castaneum - University of Wisconsin

Red flour beetle

Intended use

Reduction of spoilage of stored grains caused by this species

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Wade MJ

Institution

University of Wisconsin, USA

Publications

Authors name for system

NA – preliminary theoretical study

Class of Technology

Homing gene drive

Field(s) of application

Agriculture

Description of system

Homing CRISPR

Description

Propose CRISPR gene drives targeting genes essential for female fertility (Ace2) or male fertility (TC010993).

Notes on readiness of technology

Used modelling and sequence data from different populations to assess the feasibility of two possible suppression gene drive designs.

Phenotype

Infertile males or females.

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication