Funding for preliminary work towards homing CRISPR gene drives in Lutzomyia longipalpis species complex - London School of Hygiene and Tropical Medicine

Sandfly

Intended use

Reduction in transmission of Leishmania infantum by this vector (to reduce occurrence of visceral leishmaniasis disease)

Readiness of Technology

2b - Gene drive proposed with preliminary laboratory work funded

Project leader

Yeo M

Institution

London School of Hygiene and Tropical Medicine

Publications

Authors name for system

NA – preliminary study only

Class of Technology

Homing gene drive

Field(s) of application

Vector control

Description of system

Homing CRISPR

Description

Proposes deriving ‘insect vectors refractory to disease agents mediated by CRISPR gene drive’.

Notes on readiness of technology

Preliminary research to apply CRISPR based molecular biology tools in this species funded in 2017. Nothing published yet.

Phenotype

Proposed design would involve engineering ‘vectors refractory to disease agents’.

Authors name for construct(s)

NA – preliminary study only

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population modification/replacement