Gene Drive Projects
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Animalia
Arthropoda (incl. insects and spiders)
Insecta (insects)
Diptera (true flies)
Culicidae (mosquitoes)
Anopheles (marsh mosquitoes)
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of pathogens (including malaria and lymphatic filariasis) by these vectors in North America
Type of system
Homing CRISPR (probably)
No common name
Readiness of Technology
3 - Preliminary laboratory work publishedIntended use
Reduction of transmission of malaria pathogen by this vector and/or 'field trials in a developed country'
Type of system
Homing CRISPR targeting the Agcd gene (as described by Carballar -Lejarazu et al., 2020)
western malaria mosquito
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of pathogens (including malaria and lymphatic filariasis) by these vectors in North America
Type of system
Homing CRISPR (probably)
No common name
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Unspecified - probably would be derived from systems developed by Gates Foundation in An. gambiae
No common name
Publications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Probably homing CRISPR
No common name
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting doublesex gene
No common name
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
NA - preliminary study only
African malaria mosquito
Readiness of Technology
7 - Large cage trialsPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting doublesex gene
African malaria mosquito
Readiness of Technology
7 - Large cage trialsPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
'X-shredder' autosomal sex ratio distorter (I-Ppo 1 based)
African malaria mosquito
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Autosomal sex ratio distorter 'X-shredder' (CRISPR based)