Gene Drive Projects
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Animalia
Arthropoda (incl. insects and spiders)
Insecta (insects)
Diptera (true flies)
Culicidae (mosquitoes)
Anopheles (marsh mosquitoes)
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of pathogens (including malaria and lymphatic filariasis) by these vectors in North America
Type of system
Homing CRISPR (probably)
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Autosomal sex distorter -‘X-shredder’
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR targeting the Agcd (cardinal) gene
Readiness of Technology
2a - Gene drive proposed with supporting theoretical workPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting doublesex gene
Readiness of Technology
6 - Laboratory proof of conceptPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Autosomal sex distorter -‘X-shredder’ (I-PpoI based)
Readiness of Technology
6 - Laboratory proof of conceptIntended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive variant - the homing gene drive element promotes inheritance of 'the antimalarial Lipophorin::Sc2A10 allele' at a second genomic loci
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR targeting the Agcd (cardinal) gene
Readiness of Technology
3 - Preliminary laboratory work publishedPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing gene drive targeting doublesex gene
Readiness of Technology
5 - Limited proof of concept in laboratoryPublications
Intended use
Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)
Type of system
Homing CRISPR targeting the Agcd (cardinal) gene with compound cargo constructs. Two different strains generated named AcTp24 and AcTp43.