‘X-shredder’ (I-PpoI based) in Anopheles gambiae - Imperial College

African malaria mosquito

Intended use

Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)

Readiness of Technology

7 - Large cage trials

Project leader

Crisanti A

Institution

Imperial College London, UK

Publications

Authors name for system

Synthetic sex ratio distortion system

Class of Technology

Sex ratio distorter

Field(s) of application

Vector control

Location of proposed release

Description of system

'X-shredder' autosomal sex ratio distorter (I-Ppo 1 based)

Description

I-PpoI nuclease based autosomal ‘X-shredder’ sex ratio distorter.

(Mendelian inheritance)

Notes on readiness of technology

Shows functionality in large cage trials (Facchineli et al., 2019)

Note: a closely related strain introgressed into A. arabiensis in small cage experiments (Bernardini et al., 2019)

Research in target organism

✔

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication