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T-haplotype based sex ratio distorter gene drive with Sry cargo in Mus musculus - North Carolina State University
Mus musculus
House mouse
Intended use
Eradicating invasive populations on islands to address biodiversity impacts
Readiness of Technology
4a - Active research on gene drive construction
Project leader
Godwin J
Institution
North Carolina State University, USA
Publications
Leitschuh et al., 2018
Campbell et al., 2019
Authors name for system
T-complex drive
Class of Technology
Other gene drive system
Sex ratio distorter
Field(s) of application
Conservation
Additional notes
Sry is a Y-chromosomal gene responsible for sex determination (sex-determining region Y) and is required for initiating male development. It is also described as the male phenotype control gene in females.No results published despite substantial funding.
Description of system
T-haplotype sex ratio distorter (carrying Sry cargo)
For specialists
Research in target organism
✖
Research in model organism
✖
Intended for release
✖
Intended direct effects
Population suppression/eradication