Split homing gene drive variant to modify FREP1 in Anopheles gambiae - UC San Diego

African Malaria mosquito

Intended use

Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)

Readiness of Technology

5 - Limited proof of concept in laboratory

Project leader

Bier E

Institution

University of California San Diego, USA

Publications

Authors name for system

linked allelic drive

Class of Technology

Split homing gene drive

Field(s) of application

Vector control

Description of system

Split homing CRISPR variant causing a modification of the linked FREP1 gene

Research in target organism

✔

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population modification/replacement