Preliminary work towards a homing CRISPR gene drive targeting doublesex gene in Anopheles arabiensis - Imperial College London

Intended use

Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Hancock PA

Institution

Imperial College London, UK

Project leader

Diabate A

Institution

Institut de Recherche en Sciences de la Santé, Burkina Faso

Publications

Hancock et al., 2024

Kientega et al., 2024

Authors name for system

population suppression gene drive targeting the dsx gene

Class of Technology

Homing gene drive

Field(s) of application

Vector control

Additional notes

This work forms part of the Target Malaria project to 'suppress' the Anopheles gambiae species complex with a homing gene drive targeting the doublesex gene

Description of system

Homing gene drive targeting doublesex gene

For specialists

Research in target organism

✔

Research in model organism

✖

Intended for release

✔

Intended direct effects

Population suppression/eradication