Preliminary work towards a homing CRISPR gene drive or ‘Y-linked X shredder’ in Rattus rattus - University of Adelaide

Common rat or black rat

Intended use

Eradication of this species at continental scale, presumably in Australia, to address impacts on biodiversity

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Prowse TAA

Institution

University of Adelaide, Australia

Publications

Authors name for system

shredding drive (‘driving-Y’) or ‘CRISPR homing drive targeting female fertility’

Class of Technology

Homing gene drive

Other gene drive system

Sex ratio distorter

Field(s) of application

Conservation

Description of system

Homing CRISPR or ‘Y-linked X shredder’- Y-chromosome-linked X-shredder

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication