Preliminary work towards homing CRISPR & Cleave and Rescue and CRISPR combination, with ‘daisy-field’ in Sciurus carolinensis - University of Edinburgh

Grey squirrel

Intended use

To ‘control a targeted grey squirrel population’ to reduce impacts on biodiversity and damage to property in the UK (where it is invasive)

Readiness of Technology

2a - Gene drive proposed with supporting theoretical work

Project leader

Gorjanc G

Institution

Roslin Institute, University of Edinburgh, UK

Publications

Authors name for system

HD-ClvR: ‘composed of homing (H), daisyfield (D), and cleave-and-rescue (ClvR) gene drives’ (a highly speculative and complex drive)

Class of Technology

Homing gene drive

Toxin antidote gene drive

Other gene drive system

Field(s) of application

Conservation

Description of system

Homing CRISPR + Cleave and Rescue [Toxin Antidote] CRISPR combination, with ‘daisy-field’

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication