Preliminary work towards a gene drive in Plutella xylostella - Fujian Agriculture and Forestry University

Diamond back moth

Intended use

Reduction of damage to cruciferous crops by this species

Readiness of Technology

3 - Preliminary laboratory work published

Project leader

You MS

Institution

Fujian Agriculture and Forestry University, China

Publications

Authors name for system

NA – preliminary study only

Class of Technology

Not stated

Field(s) of application

Agriculture

Description of system

Not specified but study uses CRISPR-Cas9 gene knockout methodology, so homing CRISPR seems likely

Description

Propose targeting a gene drive to Vitellogenin receptor to interfere with reproduction.

Notes on readiness of technology

Propose the Vitellogenin receptor as a ‘genetic-based molecular target’ for control of P. xylostella.

Phenotype

Vitellogenin receptor knockout interferes with egg development and reduces hatching rate

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication