Homing gene drive in Ceratitis capitata targeting tra- Imperial College London

Mediterranean fruit fly (Medfly)

Intended use

Reduction of damage to fruit crops caused by this species

Readiness of Technology

5 - Limited proof of concept in laboratory

Project leader

Meccariello A

Institution

Imperial College London UK

Project leader

Windbichler N

Institution

Imperial College London UK

Publications

Authors name for system

Sex conversion gene drive

Class of Technology

Homing gene drive

Field(s) of application

Agriculture

Additional notes

A gene drive targeting white-eye only is also described in Mecarriello et al., 2024 which would not be expected to cause population suppression.

Description of system

Homing gene drives targeting white-eye gene and disrupting transformer (tra) in trans, OR targeting tra directly

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication