Homing CRISPR targeting doublesex gene in Anopheles gambiae variant with X shredder - Imperial College

African malaria mosquito

Intended use

Reduction of transmission of malaria pathogen by this vector (to reduce morbidity and mortality from malaria in Sub-Saharan Africa)

Readiness of Technology

6 - Laboratory proof of concept

Project leader

Bernardini F

Institution

Imperial College London UK

Publications

Authors name for system

Male drive female sterile (MDFS) plus X-shredder

Class of Technology

Homing gene drive

Sex ratio distorter

Field(s) of application

Vector control

Description of system

Homing gene drive targeting doublesex gene - male drive female sterile variant - with autosomal X shredder

Research in target organism

✔

Research in model organism

✖

Intended for release

✔

Intended direct effects

Population suppression/eradication