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Tracking plans to genetically modify wild species
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Homing CRISPR gene drive targeting female fertility in Mus musculus- University of Edinburgh
Mus musculus
House mouse
Intended use
The aim is to improve pest control methods according to 2017 press release.
Readiness of Technology
4a - Active research on gene drive construction
Project leader
Whitelaw CBA
Institution
Roslin Institute, University of Edinburgh, UK
Project leader
Lillico SG
Institution
Roslin Institute, University of Edinburgh, UK
Publications
Roslin Institute, 2017
McFarlane, Whitelaw and Lilico, 2018
McFarlane et al., 2020
Authors name for system
‘Homing gene drive targeting female fertility’ (McFarlane, Whitelaw and Lillico, 2018); ‘CRISPR-Cas9 split gene drive which disrupts an essential female fertility gene’ (McFarlane et al., 2020)
Class of Technology
Homing gene drive
Split homing gene drive
Field(s) of application
Other
Additional notes
No results published except poster abstract
Description of system
Homing CRISPR (targeting ‘haplosufficient female fertility gene’)
For specialists
Research in target organism
✖
Research in model organism
✖
Intended for release
✖
Intended direct effects
Population suppression/eradication