Tracking plans to genetically modify wild species
Homing CRISPR gene drive targeting kynurenine hydroxylase white gene (kh) with recoded kh cargo (no anti-malarial cargo genes)
(subject to emergence of resistance)
Limited proof or principle – drive appears to function with no cargo (Adolfi et al., 2020).
However ‘frequent drive-resistant mutant alleles’ reported when drive is passed through females (Terradas et al., 2022)
Green fluorescence eye marker
Reckh (‘Recoded’-kh)