Attempt to develop 'X-poisoning' sex ratio distorter in Anopheles gambiae - Hebrew University of Jerusalem

Anopheles gambiae (s.s)

Intended use

Presumably reduction of transmission of malaria by this vector.

Readiness of Technology

4b - research on gene drive construction has taken place but evidence so far shows this approach doesn't work

Project leader

Papathanos PA

Institution

Hebrew University of Jerusalem

Publications

Haber et al., 2024

Authors name for system

'X-poisoning' and/or 'X-shredding'

Class of Technology

Sex ratio distorter

Field(s) of application

Vector control

Description of system

An attempt to construct a sex ratio distorter based on 'X-poisoning, which eliminates females inheriting disrupted X-chromosomes'. Instead the system appears to function via 'X-shredding,' , i.e. the elimination of X-bearing sperm.

For specialists

Research in target organism

✖

Research in model organism

✖

Intended for release

✖

Intended direct effects

Population suppression/eradication